1. Common Side Effects

Typically mild to moderate and often temporary as your body adjusts:

• Gastrointestinal (GI): The most frequently reported symptoms:
  • Nausea (up to ~44%), vomiting, diarrhea, constipation, abdominal pain, bloating, acid reflux, indigestion, belching, gas
    NCBILloydsPharmacy Online Doctoreudoctor.orgReddit
• Other general symptoms:
  • Headache, fatigue/tiredness, dizziness, burping, upset stomach, nasal or throat irritation (common cold-like symptoms)
    LloydsPharmacy Online DoctorDrugs.comWebMD

2. Less Common but Clinically Important Side Effects

These are less frequent but warrant attention and possibly medical follow-up:

• Hypoglycemia (low blood sugar): Particularly in people with type 2 diabetes or those using insulin/sulfonylureas
  eudoctor.orgWegovyWebMD
• Pancreatitis: Inflammation of the pancreas—seek immediate help if you experience persistent upper abdominal pain that radiates to your back
  WegovymedinoWebMD
• Gallbladder issues: Gallstones, cholecystitis, or related symptoms (e.g., upper abdominal pain, jaundice)
  eudoctor.orgWegovymedino
• Kidney problems/dehydration: Vomiting, diarrhea, or nausea may lead to dehydration and worsening kidney function
  WegovyWebMD
• Severe allergic reactions: Rare but serious—swelling, rash, facial/lip/throat swelling, difficulty breathing require immediate attention
  eudoctor.orgWegovyWebMDCleveland Clinic
• Increased heart rate (tachycardia): Mild but may be noticeable as a resting heart rate increase
  eudoctor.orgWegovyWebMD
• Vision changes: Especially in those with diabetic retinopathy—monitor for visual disturbances
  WegovyWebMD
• Mood changes, depression, suicidal thoughts: Uncommon but serious—report any new or worsening mental health symptoms promptly
  WegovyWebMDCleveland Clinic

3. Warning: Thyroid Tumor Risk

• Thyroid C‑cell Tumors (rodent studies): Semaglutide caused thyroid tumors in rodents. Human relevance is unknown, but the risk remains a concern.
• Contraindications: Those with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome should not take Wegovy
  Drugs.comWegovyeudoctor.org

4. Rare or Emerging Concerns

Newer findings or very rare side effects being monitored:

• Eye-related issues:
  • Non‑arteritic anterior ischemic optic neuropathy (NAION) — a rare but serious eye event reported in up to 1 in 10,000 users
    Wikipedia
  • Neovascular age-related macular degeneration (nAMD) risk slightly increased (~0.2% vs. 0.1%) in a Canadian observational study
    Wikipedia
• Hair loss (alopecia): Semaglutide users showed a ~50% higher risk compared to some other weight-loss medications. Overall incidence in trials was around 2–2.5%
  New York PostWikipedia

5. Summary Table

Final Thoughts

Wegovy (Semaglutide) is an effective weight-management medication, but like any treatment, it carries potential side effects—mostly digestive issues at first, which often improve with dose adjustments. Serious effects are rare but can be severe, underscoring the importance of medical supervision throughout your treatment.

If you’d like, I can help you plan for side effect management strategies, like dietary tweaks, hydration, or how to taper doses to minimize discomfort. Just let me know!